JAK Inhibitor I

JAK Inhibitor I, JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC?? = 15 nM), JAK2 (IC?? = 1 nM), JAK3 (K? = 5 nM) and Tyk2 (IC?? = 1 nM).